mRNA Delivery System Testing
With the development of bioscience and nanotechnology, a broad range of materials and various combinations have been developed to form delivery vehicles with better performance that can efficiently transport IVT mRNA to target cells in vivo. The field of nanoparticles has received much attention for its potential to allow for targeted identification and treatment of diseased tissues. Creative Biogene is a leading service provider in mRNA-based drug research and development (R&D). In addition to the development of mRNA delivery systems, we also strive to offer a series of mRNA delivery systems testing services. For mRNA delivery systems testing, we focused on the identification and testing of nanoparticles, including the physical characterization, the intracellular uptake measurement, pharmacokinetics, biodistribution, and immunogenicity testing. We accept a range of particle types for testing, including synthetic polymer particles, liposome formulations, micellar nanoparticles, protein nanoparticles and many others. In particular, our services can be tailored to suit particular needs at every stage of our customers' projects.
Each class of nanoparticle (NP) features multiple subclasses, with some of the most common highlighted here. (Mitchell, M. J., et al., 2020).
Major advantages of nanoparticles as a drug delivery system
- The size and surface charge of the nanoparticles are easily altered.
- The release of medicaments can be controlled via altering the property of the matrix of nanoparticles.
- Nanoparticles are generally comprised of biodegradable materials, thus do not remain in the body.
- Nanoparticles biodistribution in the body could be regulated as per outer surface characteristics.
- Nanoparticles can be designed for various administration routes, such as oral, nasal, and parenteral delivery.
mRNA delivery systems testing—nanoparticle characterization
With over decades of experience, Creative Biogene is a leader in the area of nanoparticle characterization for drug delivery. We can provide analyses to characterize your nanoparticles, providing detailed information about your product in terms of a series of physical characterizations. Besides, we also offer biofunctionality testing, involving pharmacokinetics, immunogenicity and toxicity and among others. In addition, we offer the following services, but not limited to them.
- Physical characterization of nanoparticles，including their size, morphology, charge, and encapsulation efficiency analysis
- Nanoparticle intracellular uptake measurement
- Nanoparticle phagocytic uptake testing
- Nanoparticle pharmacokinetics and biodistribution testing
- Nanoparticle immunogenicity and toxicity testing
Benefits of our services
Integrated with delivery system formulation
Our nanoparticle characterization service is combined with the delivery system development service. Our nanoparticle characterization and formulation teams work closely together to support better characterization as well as formulation development.
Years of accumulated experience in nanoparticle characterization and analysis
Our technicians are professionally trained in the area of nanoparticle characterization and analysis. Over the years, we have accumulated a great deal of experience working with many customers from all over the world.
An optimized and well-established platform
At present, nanoparticles can be characterized by various methods without a standard. To better characterize nanoparticles and advance the downstream application, we provide a systematic protocol for nanoparticle characterization based on multiple technologies and state-of-the-art instruments. Our technologies are extensive, including transmission electron microscopy (TEM), zeta potential analysis, nanoparticle tracking analysis (NTA) technology, biofunctionality testing, and so on.
Simply let us know about your research needs. We will propose the best strategy to best match your research objectives. Contact us right now! We will respond rapidly to your inquiry.
References
- Mitchell, M. J., et al. (2020). "Engineering precision nanoparticles for drug delivery." Nature Reviews Drug Discovery, 1-24.
- Gupta, V., & Trivedi, P. (2018). "In vitro and in vivo characterization of pharmaceutical topical nanocarriers containing anticancer drugs for skin cancer treatment." Lipid nanocarriers for drug targeting. William Andrew Publishing, 2018. 563-627.