mRNA Manufacturing Services
The development and use of mRNAs as a novel class of drug modalities has shown a great potential in the treatment of a wide variety of human diseases, including infectious disease, cancers, and genetic disorders and so on. Modified in vitro (IVT) mRNAs have proved to be viable and safe, and can be applied in vaccination, protein replacement therapy, antibody therapy and among others. To successfully bring mRNA-based drugs, it is critical to control the manufacturing as well as supply processes. Therefore, Creative Biogene now is executing highly efficient strategies and providing a series of services to satisfy global clients' demands of custom mRNA production and large-scale manufacture.
Service offering
The structural elements of the mRNA have an impact on its performance, including stability, translation efficiency and potential immunogenicity of the molecule. We leverage our extensive experience to conduct combinatorial design and adapt its composition to suit the desired application based on the best algorithm for predicting mRNA structure and the robust design software. We have the capacity to design mRNA that codes for desired proteins at a very low cost within days.
Based on our dedicated platform, we can synthesize high-quality mRNAs from milligrams to multi-grams in scales, and from a few hundred nucleotides to more than 10 kilobases in length. We not only pay much attention to the quality and speed, but also to customers’ projects scalability and cost. Particularly, both research-grade or GMP-grade mRNA can be customized according to our customers’ research goals.
Purification of IVT mRNA services
With the increasing importance of IVT mRNA, the manufacturing of pure mRNA products are demands. The purity of IVT mRNA is a key factor in determining the efficiency of target antigen expression. To enhance the concentration and quality of IVT mRNA and meet the special needs of customers, we are dedicated to offering IVT mRNA purification service based on many techniques, including high performance liquid chromatography (HPLC), fast protein liquid chromatography (FPLC) and magnetic beads technology.
mRNA Pharmacology Optimization Services
As a leading customized service provider in the field of mRNA-based drugs discovery and development. We are committed to systematically improving the intracellular stability, translational efficiency of IVT mRNAs and modulating its immunogenicity, aiming to provide the basis for a broad spectrum of potential applications.
Creative Biogene offers a series of mRNA manufacturing services which are part of our integrated portfolio of mRNA-based drug research and development services. As a leading service provider of mRNA-based drug research and development service, our extensive experience, excellent team of experts and advanced instruments, make us an ideal partner for worldwide customers. We can support our customers with the most affordable, high-quality custom mRNAs according to the desired applications in a timely and professional manner.